Hemophilia is often called the
"royal disease". This is because British monarch Queen Victoria’s
descendants we afflicted with this health issue. Many of her sons and grandsons
died of bleeding out at a young age; many of her daughters were the carriers of
the infected gene. The disease spread throughout Europe as Queen Victoria’s
descendants married into the Royal houses of Russia, Spain, and Germany.
Russian Tsar Nicholas II married Alix of Hesse, later Alexandra Feodorovna
Romanova, the granddaughter of Queen Victoria. Nicholas and Alexandra had a
son, Alexei, who had Hemophilia B. Alexi bled often, and his frail condition
played a significant role in Russian Revolution.
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